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馬登科

姓名:馬登科

性別:男

職稱:教授

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招生院所:澳門新葡官網進入化學生物學系

招生類型:博士研究生、碩士研究生

招生專業:藥物化學(科學學位)

研究方向名稱:手性藥物發現、設計與綠色合成及活性研究

電子信箱:madk@ccmu.edu.cn

個人簡介

博士,澳門新葡官網進入化學生物學系,教授,博士生導師。2017年6月博士畢業于浙江大學化學系,師從麻生明教授(中科院院士)。2017年8月在香港科技大學Jianwei Sun教授課題組從事博士后研究。2019年10月在西班牙加泰羅尼亞化學研究所(ICIQ)Paolo Melchiorre教授課題組從事博士后研究,同時入選歐盟瑪麗居里學者人才計劃。2022年4月入職澳門新葡官網進入化學生物學系,開展獨立研究工作。主要從事不對稱催化與合成,光催化,合成電化學,以及藥物分子發現、設計與合成等方面的研究。目前已經在 J. Am.   Chem. Soc. ,  Angew. Chem. Int. Ed. ,  Org. Lett. ,  Chem. Commun. ,  Org.   Chem. Front. 等期刊發表學術論文18篇,包括 J. Am.   Chem. Soc.  (1篇), Angew.   Chem. Int. Ed.  (3篇)。研究工作多次被Highlight或入選HOT paper。獲得授權中國發明專利2項。

教育經歷

2008.9?2012.6,鄭州大學材料科學與工程學院,材料科學與工程(高分子材料),學士

2012.9?2017.7,浙江大學化學系,化學,博士

工作經歷

2017.8?2019.8,香港科技大學化學系,博士后

2019.10?2021.9,西班牙加泰羅尼亞化學研究所(ICIQ),博士后

2022.4?至今,澳門新葡官網進入,教授

重要學術論文:

1. Wong, H.-F. T.; Ma, D.; Di Sanza, R.; Melchiorre, P.*   Photoredox Organocatalysis for the Enantioselective Synthesis of   1,7-Dicarbonyl Compounds.  Org. Lett.   2022,  24 , 1695.

2. Le Saux. E.; + Ma, D.; + Bonilla, P. ; Holden, C.   M. ; Lustosa, D. ; Melchiorre, P.* A General Organocatalytic System   for Enantioselective Radical Conjugate Additions to Enals.  Angew. Chem., Int. Ed.  2021,  60 , 5357. ( equal contribution ) (HOT paper & Highlighted by  Synfacts   2021,  17 , 325.)

3. Wong,   T. H. M.; Li, X.; Ma, D.; Sun, J.*   HNTf2-Catalyzed Synthesis of Hydrodibenzofurans by an   Epoxidation/Semipinacol Rearrangement Cascade.  Org. Lett. 2020,  22 , 1951.

4. Ma, D.;   Miao, C.; Sun, J.* Catalytic Enantioselective House?Meinwald Rearrangement: Efficient Construction of   All-Carbon Quaternary Stereocenters.  J.   Am. Chem. Soc. 2019,  141 , 13783.

5. Ma, D.;   Zhang, Z.; Chen, M.; Lin, Z.; Sun, J.* Organocatalytic Enantioselective   Functionalization of Unactivated Indole C(sp3)?H Bonds.  Angew. Chem., Int. Ed. 2019,  58 , 15916.

6. Zhang,   Z.; Yan, J.; Ma, D.; Sun, J.*   Electrochemical Synthesis of β-Hydroxy-, β-Alkoxy-, and β-Carbonyloxy   Sulfones by Vicinal Difunctionalization of Olefins.  Chin. Chem. Lett . 2019,    30 , 1509.

7. Yang, W.; + Ma, D.; + Zhou, Y.; Dong, X.; Lin, Z.; Sun, J.* NHC‐Catalyzed Electrophilic   Trifluoromethylation: Efficient Synthesis of γ‐Trifluoromethyl   α,β‐Unsaturated Esters.  Angew. Chem.,   Int. Ed. 2018,  5 7,   12097. ( equal contribution )

8. Ma, D.; Song, Y.; Fu, C.; Zhang, F.; Guo, Y.; Huang,   X.;* Ma, S.*  E -Selective  N -heterocyclic Carbene-catalyzed   Reaction of Aldehydes and Butadienoates: Effect of Water and Chloroform as   the Proton Shuttle.  Org. Chem. Front .   2018,  5 , 2560. (Organic Chemistry Frontiers HOT articles   for 2018)

9. Ma, D.; Duan,   X.; Fu, C.; Huang, X.;* Ma, S.* Dimethylprinol vs. Diphenylprinol in CuBr2-catalyzed   Enantioselective Allenylation of Terminal Alkynols.  Synthesis  2018,  50 , 2533. ( Reported by Thieme Chemistry as News-Archive:   2018,   https://www.thieme.de/en/thieme-chemistry/organocatalytic-enantioselective-synthesis-of-disubstituted-allenols-132083.htm)  

10. Chen, M.;+ Han, Y.; + Ma, D.; + Wang, Y.; Lai,   Z.; Sun, J.* Organocatalytic Enantioselective Synthesis of Chiral   Diarylmethylamines from Racemic Alcohols.  Chin.   J. Chem . 2018,  36 , 587. ( equal contribution )

11. Luo,   H.; Ma, D.; Ma, S.* Preparation of Buta-2,3-dien-1-ol.  Org.   Synth . 2017,  94 ,    153 .

12. Ma, D.; Fu, C.; Ma, S.* Diastereoselective Construction of   Cyclopent-2-enone-4-ols from Aldehydes and 1,2-Allenones Catalyzed by  N -Heterocyclic Carbene.  Chem. Commun . 2016,  52 , 14426.

13. Dai, J.; Ma, D.; Fu, C.; Ma, S.* Gram Scale Total   Synthesis of 2-Hydroxy-3-methylcarbazole, Pyrano[3,2- a ]carbazole and Prenylcarbazole Alkaloids.  Eur. J. Org. Chem . 2015,   5655.

14. Ma, D.; Dai, J.; Qiu, Y.; Fu, C.;* Ma, S.* Gram Scale Synthesis of   7-Methoxy- O -methylmukonal,   Clausine-O, Clausine-K, Clausine-H, 7-Methoxymukonal, and Methyl   2-hydroxy-7-methoxy-9 H -carbazole-3-carboxylate.    Org. Chem. Front . 2014,  1 , 782.

15. Ma, D.; Qiu, Y.; Dai, J.; Fu, C.;   Ma, S.*  N -Heterocyclic Carbene-Promoted Annulation Reaction of Allenals   with Chalcones: Synthesis of Polysubstituted Pyranyl Aldehydes,  Org. Lett . 2014,  16 , 4742. (Highlighted by  Synfacts   2014,  10 , 1139.)

16. Qiu, Y.; Ma, D.; Kong, W.; Fu, C.; Ma, S.*   Regiocontrolled 1,2-Migration in Cyclization of 1-(indol-2-yl)-3-alkyn-1-ols:   (Ph3P)Au+ vs. PtCl4.  Org. Chem. Front . 2014,    1 , 62.

17. Qiu, Y.; Ma, D.; Fu, C.;* Ma, S.* An Efficient   Au-catalyzed Synthesis of Isomukonidine, Clausine L, Mukonidine, Glycosinine,   Mukonal, and Clausine V from Propadienyl Methyl Ether.  Org. Biomol. Chem . 2013,    11 , 1666.

18. Qiu, Y.; Ma, D.; Fu, C.; Ma, S.* General Approach to   Benzo[ b ]thiophenes, Benzo[ b ]furans, and Dibenzofurans via   Gold-catalyzed Cyclization of 1-Heteroarylalka-2,3-dienyl acetates.  Tetrahedron 2013,  69 , 6305.

承擔重要項目

894795,光催化在藥物開發中的應用-不對稱合成生物活性的手性內酯和環己醇化合物(Photocatalysis in Drug   Discovery–Asymmetric Preparation of Bioactive Chiral Lactones and   Cyclohexanols),歐盟瑪麗居里學者人才計劃,160,932歐元(約合115.6萬元人民幣), 2020-03 至 2022-02。

重要獎項

2020:   European Commission: Marie Sk?odowska-Curie Individual Fellowships 歐盟瑪麗居里學者人才計劃



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